3-Hydroxyleukotriene B4 (3-OH-LTB4): total synthesis and stereochemical assignment

Triply convergent strategy is used for the sequential union of propargylic arsonium salts with pyranosides and furanose to enable the total asymmetric synthesis of 3-hydroxyleukotriene B4(3-OH-LTB4). Palladium-mediated coupling is the vital step in the process. 3(S)-isomer is the major component in the enzyme produced product. Chromatography and mass spectra are employed for stereochemical assignment.