Organocatalytic enantioselective conjugate additions to enones

An efficient and general conjugate addition of a broad spectrum of nucleophilic enol species to enones, catalyzed by a cinchona alkaloid derived thiourea organocatalyst, is reported. The reaction affords excellent enantioselectivity and high yields for a diverse array of nucleophiles, including malonate esters, ketoesters, 1,3-diketones, nitroesters, and 1,3-dinitriles and enones as electrophiles.