Hox11 controls the genesis of the spleen

Authors :: Roberts, Charles W.M.
Shutter, John R.
Korsmeyer, Stanley J.
Source :: Nature. April 21, 1994, Vol. 368 Issue 6473, p747, 3 p.
Publication Year :: 1994
Abstract: Studies of Hox11-/- genes lacking spleen reveal that, despite the absence of cellular organization at the site of splenic development, other splanchnic derivatives develop normally. Hox11 gene appear to control the organogenesis of spleen. The Hox11 ablation results in asplenia.