Two-dimensional lipid mixing entropy regulates the formation of multicomponent lipoplexes

An investigation of the mechanism of formation of multicomponent lipoplexes is presented by means of synchrotron Small-Angle X-ray diffraction (SAXD). The equilibrium structure of multicomponent lipoplexes is found to be unique and did not depend on the number and kind of populations composing lipid dispersion but only on the lipid species involved and on their relative molar ratio.