Congruent multiple Michael addition for the synthesis of biomimetic heme analogues

Authors :: Collman, James P.
Zhang, Xumu
Herrmann, Paul C.
Uffelman, Erich S.
Boitrel, Bernard
Straumanis, Andrei
Brauman, John I.
Source :: Journal of the American Chemical Society. March 23, 1994, Vol. 116 Issue 6, p2681, 2 p.
Publication Year :: 1994
Abstract: A potent general procedure is proposed for the synthesis of analogues of various heme protein active regions. The convergent multiple Michael addition forms the basis of this methodology to prepare biomimetic model hemes. A Fe (II) porphyrin which binds dioxygen reversibly and a mercaptide Fe(II) carbonyl complex with the special spectral properties of cytochrome P-450.

Subjects :: Hemoproteins -- Research
Addition polymerization -- Analysis
Porphyrins -- Analysis
Chemistry

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