Biphasic brown fat temperature responses to hypothalamic stimulation in rats

Studies on brown adipose tissue response to hypothalamic stimulation in rats suggests that the initial phase 1 reduction in interscapular brown adipose tissue temperature (IBAT) is mediated through dopaminergic pathways. Amphetamine injections to the intracerebroventricular regions produce reduced IBAT temperatures resembling phase 1 phenomena. The injection of pimozide suppresses phase 1, reinforcing the role of dopaminergic mechanisms in the process.