Hypercapnic acidosis increases oxygen cost of contractility in the dog left ventricle

Left ventricle (LV) contractile dysfunction occurs along with an elevated oxygen cost of contractility in the dog due to hypercapnic acidosis. An elevated Ca2+ responsiveness of the contractile proteins during acidosis may explain this enhanced energy cost of the excitation contraction coupling. The oxygen cost of enhanced contractility was 1.53 plus or minus 0.40 times lower during preacidosis than during acidosis.