Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer

A human gene encodes a human MutL homologue protein (hMLH1) which is similar to the bacterial DNA mismatch protein MutL. The protein hMLH1 is situated on human chromosome 3p21-23. hMLH1, like the human DNA mismatch pair gene homologue hMSH2, can be related to non-polyposis colon cancer.