Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues

Authors :: Huby, Thierry
Doucet, Chantal
Dachet, Christiane
Ouzilleau, Betty
Ueda, Yukihiko
Afzal, Veena
Rubin, Edward
Chapman, M. John
Lesnik, Philippe
Source :: Journal of Clinical Investigation. Oct, 2006, Vol. 116 Issue 10, p2767, 10 p.
Publication Year :: 2006
Abstract: Scavenger receptor SR-BI has been implicated in HDL-dependent atheroprotective mechanisms. We report the generation of an SR-BI conditional knockout mouse model in which SR-BI gene targeting by loxP site insertion [...]

Subjects :: Mice -- Research
Liver diseases -- Research
Medical research
Medicine, Experimental

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