Effects of potassium channel blockers on basal vascular tone and reactive hyperemia of canine diaphragm

Experiments on basal tone regulation in anesthetized dogs reveals that glibenclamide-sensitive potassium channels partially regulate the baseline resistance and reactive hyperemia of the diaphragm. Glibendamide causes a dose-dependent reversal of lemakalim-induced vasodilation whereas iberiotoxin and apamin do not. Lemakalim perfusion, in isolation, causes a drastic lowering of phrenic resistance.