Au(l)-catalyzed annulation of enantioenriched allenes in the enantionselective total synthesis of (-)-rhazinilam

The enantioselective total synthesis of (-)-rhazinilam is reported which demonstrates the success of this reaction design using Au(I)-catalyzed pyrrole-allene additions. Asymmetric Au(I)-catalyzed pyrrole additions to enantioenriched allenes afford a unique entry to optical active heterocycles.