A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

Authors :: Dyck, Jacqueline A.
Maul, Gerd G.
Miller, Wilson H., Jr.
Chen, J. Don
Kakizuka, Akira
Evans, Ronald M.
Source :: Cell. Jan 28, 1994, Vol. 76 Issue 2, p333, 11 p.
Publication Year :: 1994
Abstract: The promyelocyte-retinoic acid receptor (PML-RAR-alpha) protein is possibly a dominant negative oncogene that targets a nuclear matrix-associated structure. PML-RAR inhibits the formation of structures that are designated PML oncogenic domains (POD). Immunohistochemical and functional techniques reveal that PML-RAR forms heterodimers and is localized in the nucleus of leukemic cells. PML-RAR oncoprotein expression disrupts POD in acute promyelocytic leukemia cells.

Subjects :: Oncogenes -- Research
Gene expression -- Observations
Acute leukemia, Promyelocytic -- Analysis
Immunohistochemistry -- Usage
Biological sciences

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