Electrostatic basis for enzyme catalysis

An explanation is provided on the origin of the catalytic power of enzymes by clarifying the confusions regarding the reference state by introducing a catalytic scale that does not include the well understood effect of having different mechanisms in the enzyme and in solution as well as the affect of the binding of the reactant state. A demonstration is presented that the effect of the enzyme environment can be much larger than the estimated 15 kcal/mol