The bogoral family of antibiotics: Template-based structure elucidation and a new approach to positioning enantiomeric pairs of amino acids

The sequence positions of D and L Leu and Lys residues in bogorol A are defined by a novel method that uses small amounts of sample and focuses on detecting the order in which amino acids are liberated from the parent peptide during acid-catalyzed hydrolysis. The bogorols represent a new cationic peptide antibiotic template and have displayed selective and relatively potent activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus spp. (VRE), as well as moderate activity versus Escherichia coli.