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The bogoral family of antibiotics: Template-based structure elucidation and a new approach to positioning enantiomeric pairs of amino acids
- Source :
- Journal of Organic Chemistry. August 4, 2006, Vol. 71 Issue 16, 6031-6037
- Publication Year :
- 2006
-
Abstract
- The sequence positions of D and L Leu and Lys residues in bogorol A are defined by a novel method that uses small amounts of sample and focuses on detecting the order in which amino acids are liberated from the parent peptide during acid-catalyzed hydrolysis. The bogorols represent a new cationic peptide antibiotic template and have displayed selective and relatively potent activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus spp. (VRE), as well as moderate activity versus Escherichia coli.
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 71
- Issue :
- 16
- Database :
- Gale General OneFile
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.151830072