In search of fully uncomplexed cyclodextrin in the presence of micellar aggregates

The chemical behavior of beta-cyclodextrin/nonionic surfactant mixed systems is investigated by using the basic hydrolysis of N-methyl-N-nitroso-p-toluenesulfonamide as a chemical probe. The variations in the hydrophobicity of the surfactant monomer have helped in determining the percentages of uncomplexed cyclodextrin in equilibrium with the micellar system that are in the range of 5-95%.