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A study of the reaction of calicheamicin gamma1 with glutathione in the presence of double-stranded DNA
- Source :
- Journal of the American Chemical Society. Feb 23, 1994, Vol. 116 Issue 4, p1255, 17 p.
- Publication Year :
- 1994
-
Abstract
- The calicheamicin gamma1 and glutathione reaction in the presence of double-stranded DNA yields four products generated by S-S bond exchange. The calicheamicin gamma1 bisulfide group and glutathione thiol function react to give the S-S bond product. There is no evidence of DNA catalysis of thiol function in water.
- Subjects :
- Calicheamicin -- Research
Glutathione -- Analysis
Chemistry
Subjects
Details
- ISSN :
- 00027863
- Volume :
- 116
- Issue :
- 4
- Database :
- Gale General OneFile
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.15107005