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gamma delta T cells contribute to immunity against the liver stages of malaria in alphabeta T-cell-deficient mice

Authors :
Tsuji, Moriya
Mombaerts, Peter
Lefrancois, Leo
Nussenzweig, Ruth S.
Zavala, Fidel
Tonegawa, Susumu
Source :
Proceedings of the National Academy of Sciences of the United States. Jan 4, 1994, Vol. 91 Issue 1, p345, 5 p.
Publication Year :
1994

Abstract

Gamma delta T cells confer immunity against liver and blood malarial stage to alpha beta T cell-deficient mice. Murine gamma delta T cell mutants that act against microbes define T cell recognition of the antigens. The incorporation of germ-line mutations in either the TCR alpha beta or gamma delta chain mice genes yields the alpha beta T cell lacking test mice.

Details

ISSN :
00278424
Volume :
91
Issue :
1
Database :
Gale General OneFile
Journal :
Proceedings of the National Academy of Sciences of the United States
Publication Type :
Academic Journal
Accession number :
edsgcl.15083282