Using genomic inbreeding coefficient estimates for homozygosity mapping of rare recessive traits: Application to Taybi-Linder syndrome

The interest of the approach by mapping a gene for Taybi-Linder syndrome to chromosome 2q is shown with the use of a key patient with no genealogical information. This could be achieved by estimating inbreeding coefficients from the patients' genomic information and using these estimates to perform homozygosity mapping.