Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene

Anaphylaxis is caused by the activation of most cells and basophils. The basophils are activated by immunoglobin E (IgE) and allergen. Different types of IgE receptors are expressed, and the contribution of IgE receptors is determined by the generation Fc-epsilon-RI deficient mice. The deficient mice are normal in appearance and have normal amount of mast cells, but are resistant to cutaneous reactions. This indicates that the IgE dependent anaphyloctic reaction require IgE.