Use of aromatase (CYP19) metabolite ratios to characterize electron transfer from NADPH-cytochrome P450 reductase

Authors :: Grogan, J.
Shou, M.
Zhou, D.
Chen, S.
Korzekwa, K.R.
Source :: Biochemistry. Nov 16, 1993, Vol. 32 Issue 45, p12007, 6 p.
Publication Year :: 1993
Abstract: Androstene dione metabolism is examined by isolating the microsomes of Chinese hamster ovary cells that express human aromatase. The restriction of electron flux from NADPH-cytochrome P450 reductase to aromatase results in enhanced quantities of smaller metabolites. The reactions of aromatase and oxidoreductase are indicated by the metabolite ratios.

Subjects :: Enzymes -- Usage
Charge transfer -- Research
Electrons -- Observations
Cytochromes -- Analysis
Biological sciences
Chemistry

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