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Left ventricular hypertrophy in mice with a cardiac-specific overexpression of interleukin-1

Authors :
Nishikawa, Kenichiro
Yoshida, Mikoto
Kusuhara, Masatoshi
Ishigami, Norio
Isoda, Kikuo
Miyazaki, Kohji
Ohsuzu, Fumitaka
Source :
The American Journal of Physiology. July, 2006, Vol. 291 Issue 1, pH176, 8 p.
Publication Year :
2006

Abstract

Recent studies have identified the importance of proinflammatory cytokines in the development of left ventricular (LV) hypertrophy. However, the precise role of interleukin-1 (IL-1), one of the major proinflammatory cytokines, in the myocardium is not fully understood. In this study, we investigated the pathophysiological consequences of cardiac expression of IL-1 in vivo. We generated mice with a cardiac-specific overexpression of human IL-1[alpha]. We then analyzed their heart morphology and functions. Histological and echocardiographic analyses revealed concentric LV hypertrophy with preserved LV systolic function in the mice. Our results suggest that myocardial expression of IL-1 is sufficient to cause LV hypertrophy. myocardium; left ventricular systolic function; cardiovascular disease

Details

Language :
English
ISSN :
00029513
Volume :
291
Issue :
1
Database :
Gale General OneFile
Journal :
The American Journal of Physiology
Publication Type :
Academic Journal
Accession number :
edsgcl.148716927