Protein kinase A antagonizes platelet-drived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells

Authors :: Graves, Lee M.
Bornfeldt, Karin E.
Raines, Elaine W.
Potts, Brain C.
Macdonald, Susan G.
Ross, Russell
Krebs, Edwin G.
Source :: Proceedings of the National Academy of Sciences of the United States. Nov 1, 1993, Vol. 90 Issue 21, p10300, 5 p.
Publication Year :: 1993
Abstract: Mitogen-activated protein kinase (MAPK) and MAPK kinase (MAPKK) can be rapidly activated by stimulating aortic smooth muscle cells using platelet derived growth factor BB homodiner (PDGF-BB). PDGF-BB-stimulated MAPKK and MAPK activation are inhibited by prostaglandin E2, isoproterenol, cholera toxin and forskolin. A study records the interactions between the PKA pathway and the growth factor-activated MAPK cascade.

Subjects :: Protein kinases -- Analysis
Platelet-derived growth factor -- Analysis
Smooth muscle -- Research
Muscle cells -- Analysis
Arteries -- Physiological aspects
Science and technology

ISSN :: 00278424
Volume :: 90
Issue :: 21
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.14832919

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