Selective erythroid replacement in murine beta-thalassemia using fetal hematopoietic stem cells

Authors :: Bethel, Colin A.
Murugesh, Deepa
Harrison, Michael R.
Mohandas, Narla
Rubin, Edward M.
Source :: Proceedings of the National Academy of Sciences of the United States. Nov 1, 1993, Vol. 90 Issue 21, p10120, 5 p.
Publication Year :: 1993
Abstract: Fetal hematopoietic stem cell (HSC) transplantation has the potential to play a vital role in the treatment of erythroid chimerism. HSCs from non thalassemic syngeneic murine fetal donors were transplanted into recipients with nonirradiated neonatal beta-thalassemic properties. Erythrocyte chimerism was observed in several recipients within a month.

Subjects :: Erythrocytes -- Research
Thalassemia -- Analysis
Hematopoietic stem cells -- Analysis
Embryology -- Research
Science and technology

ISSN :: 00278424
Volume :: 90
Issue :: 21
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.14832761

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