Transforming growth factor beta1 (TGF-beta1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta1 null mouse phenotype

Authors :: Geiser, Andrew G.
Letterio, John J.
Kulkarni, Ashok B.
Karlsson, Stefan
Roberts, Anita B.
Sporn, Michael B.
Source :: Proceedings of the National Academy of Sciences of the United States. Nov 1, 1993, Vol. 90 Issue 21, p9944, 5 p.
Publication Year :: 1993
Abstract: Transforming growth factor beta-1 (TGF-beta-1) regulates the expression of major histocompatibility complex (MHC) genes in postnatal mouse. TGF-beta plays an important role in the organization of autoimmune abnormalities, allograft incompatibility and other defects ascribed to modifications in MHC expression. Multifocal inflammation and deterioration syndrome, characteristic of the TGB-beta-1 null mouse is a possible consequence of changes effected in the modulation of MHC expression.

Subjects :: Transforming growth factors -- Physiological aspects
Major histocompatibility complex -- Analysis
Mice -- Research
Science and technology

ISSN :: 00278424
Volume :: 90
Issue :: 21
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.14832587

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