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Conformation-selective DNA strand breaks by dynemicin: a molecular wedge into flexible regions of DNA
- Source :
- Biochemistry. Nov 2, 1993, Vol. 32 Issue 43, p11669, 7 p.
- Publication Year :
- 1993
-
Abstract
- Various oligonucleotides possessing a nickel structure or an extended base or a mismatched base were used to examine the conformational selectivity of dynemicin. The enediyne antibiotic dynemicin identifies and divides the areas of DNA that are conformationally pliant. Dynemicin could be a molecular wedge, which, by intercalating into the smaller-groove part of conformationally pliant areas of the DNA, attaches to the DNA.
- Subjects :
- DNA -- Research
Antibiotics -- Analysis
Biological sciences
Chemistry
Subjects
Details
- ISSN :
- 00062960
- Volume :
- 32
- Issue :
- 43
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.14832299