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pH Affects both the mechanism and the specificity of peptide binding to a class II major histocompatibility complex molecule
- Source :
- Biochemistry. Nov 9, 1993, Vol. 32 Issue 44, p11761, 8 p.
- Publication Year :
- 1993
-
Abstract
- Influence of pH on the forces which participate in peptide binding causes alterations in the binding of the II class major histocompatibility complex molecule, IE(K) to peptides. Lys103 of moth cytochrome c influences the binding process of pH at 7.5. An Ala residue substitutes Lys to support binding at pH 5.4. An acidic surrounding is necessary to enable IE(K) to produce an antigenic nonpolar peptide. pH also influences the specificity and the extent of binding degeneration. High-affinity peptide analogues are generated by employing the correct forces needed for peptide binding.
Details
- ISSN :
- 00062960
- Volume :
- 32
- Issue :
- 44
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.14832079