Back to Search
Start Over
A mitotic topoisomerase II checkpoint in budding yeast is required for genome stability but acts independently of Pds1/securin
- Source :
- Genes & Development. May 1, 2006, Vol. 20 Issue 9, 1162-1174
- Publication Year :
- 2006
-
Abstract
- A topoisomerase II (Topo II)-dependent G2/M checkpoint is defined in a genetically amenable eukaryote, budding yeast, and it is demonstrated that this checkpoint enhances cell survival. Neither DNA damage-responsive pathways nor Pds1/securin are needed for this checkpoint, and compromised Topo II function activates a yeast checkpoint system that operates by a novel mechanism.
Details
- Language :
- English
- ISSN :
- 08909369
- Volume :
- 20
- Issue :
- 9
- Database :
- Gale General OneFile
- Journal :
- Genes & Development
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.147939243