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Substrates induce conformational changes in human anion exchanger 1 (hAE1) as observed by fluorescence resonance energy transfer
- Source :
- Biochemistry. May 23, 2006, Vol. 45 Issue 20, p6279, 17 p.
- Publication Year :
- 2006
-
Abstract
- Steady-state and time-resolved resonance energy transfer (FRET) techniques were used to determine the distance of the binding site for diTBA (bis-(1,3-diethylothiobarbituric acid)trimethine oxonol). The analysis indicates that diTBA binding site comes closer to the FM site by ~7 A in chloride buffer as compared to that in citrate because of the effects of anion binding.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 45
- Issue :
- 20
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.147457527