Mutational studies of G553 in TM5 of ABCG2: A residue potentially involved in dimerization

The mutating amino acid 553 in TM5 of ABCG2, a well conserved residue corresponding to glycine 589 of the Drosophila white protein, disrupts the function and trafficking that implies a similar role in the dimerization of the human transporter is reported. The results reveal that glycine 553 is important for protein trafficking and are consistent with its involvement in ABCG2 homodimerization.