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Characterization of human saposins by NMR spectroscopy
- Source :
- Biochemistry. April 25, 2006, Vol. 45 Issue 16, p5206, 11 p.
- Publication Year :
- 2006
-
Abstract
- The solution NMR spectroscopy is employed to characterize all four (super 15)N-labeled human saposins at both neutral and acidic pH. The results reveal that pH 4.0, where all saposins are highly unstable, Sap-C undergoes a transition to a specific dimeric state, which might resemble the structure found in both Sap-C in a detergent environment and crystals of Sap-B.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 45
- Issue :
- 16
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.147193153