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A hybrid vector for ligand-directed tumor targeting and molecular imaging

Authors :
Hajitou, Amin
Rangel, Roberto
Yan Sun
Trepal, Martin
Moya, Catherine A.
Zaoui, Karim
Lilley, Caroline E.; Arap, Wadih
Soghomonyan, Suren
Restel, Bradley H.
von Kalle, Christopher
Pasqualini, Renata
Source :
Cell. April 21, 2006, Vol. 125 Issue 2, p385, 14 p.
Publication Year :
2006

Abstract

A system containing cis-elements from adeno-associated virus (AAV) and single-stranded bacteriophage is introduced. It is shown that AAV/phage (AAVP) provides superior tumor transduction over phage and that incorporation of inverted terminal repeats is associated with improved fate of the delivered transgene.

Details

Language :
English
ISSN :
00928674
Volume :
125
Issue :
2
Database :
Gale General OneFile
Journal :
Cell
Publication Type :
Academic Journal
Accession number :
edsgcl.146883312