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Lactam synthesis via the intramolecular hydroamidation of alkynes catalyzed by palladium complexes

Authors :
Patil, Nitin T.
Zhibao Huo
Bajracharya, Gan B.
Yamamoto, Yoshinori
Source :
Journal of Organic Chemistry. April 28, 2006, Vol. 71 Issue 9, p3612, 3 p.
Publication Year :
2006

Abstract

The Pd(PPh3)(sub 4)-catalyzed intramolecular hydroamidation reaction of the amido alkynes is developed. This method allows the facile and efficient construction of six-membered lactams (4) in an atom-economical manner.

Details

Language :
English
ISSN :
00223263
Volume :
71
Issue :
9
Database :
Gale General OneFile
Journal :
Journal of Organic Chemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.146410791