Arginine vasopressin produces renal vasodilation via V2 receptors in conscious dogs

Minute enhancements in plasma arginine vasopressin (AVP) influence renal vasodilation in dehydrated animals. Regulation of V2 receptors are responsible for AVP actions. Direct vasodilation, hindering of sympathetic outflow and regulation by endothelium-derived relaxing factor contribute to vasodilation which is controlled by the V2 receptor. Physiological characteristics of the V2 receptor are determined. Pathophysiology of dehydration and congestive heart failure is understood due to physiological involvement of the V2 receptor in renal vessels.