Asymmetric Claisen rearrangements enabled by catalytic asymmetric di(allyl) ether synthesis

The integration of a catalytic asymmetric synthesis of di(allyl) ether substrates into an expedient, two-step protocol was reported for realizing asymmetric aliphatic Claisen rearrangements from readily available starting material. The resulting enantioenriched di(allyl) ethers constitute direct progenitors of asymmetric Claisen rearrangements by virtue of isomerization-Claisen rearrangement (ICR) technology, thereby providing a simple two-step sequence to enantioenriched Claisen adducts from easily obtained precursors.