HNF-1-alpha and HNF-1-beta expression in mouse intestinal crypts

Authors :: Serfas, Michael S.
Tyner, Angela L.
Source :: The American Journal of Physiology. Sept, 1993, Vol. 265 Issue 3, pG506, 8 p.
Publication Year :: 1993
Abstract: The expression of hepatocyte nuclear factors 1-alpha (HNF) and HNF-1-beta mRNA during growth and along the length of the intestine was studied. This study was aimed at determining the role of the two HNF-1 factors in the characterization of various intestinal epithelial cell lineages in channelizing alpha-fetoprotein (AFP) to enteroendocrine cells. The HNF factors were found to be expressed along the vertical axis of the intestine, gradiently.