Cholecystokinin octapeptide analogues suppress food intake via central CCK-A receptors in mice

A study was conducted to investigate the function which intervenes with the satiety influence of cholecystokinin (CCK) inside the central nervous system. The capacity and efficiency of peripheral and central injections of CCK-8 and those related to it on food intake in fasted mice were compared for this purpose. CCK-A, when administered centrally and peripherally, restrains food intake by an interaction with the CCK-A receptor and not with the CCK-B receptor.