Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

The binding of synthetic amyloid beta (beta/A4) peptide was compared to purified apolipoprotein E4 (apoE4) and the most common isoform, apoE3, to find if apoE4 is related to enhanced vulnerability to Alzheimer disease. The two isoforms form a complex with the beta/A4 peptide in different ways. ApoE is regionalized in the senile plaques, congophilic angiopathy and neurofibrillary tangles of Alzheimer disease.