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The acute promyelocytic leukemia-specific PML-RAR-alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells
- Source :
- Cell. August 13, 1993, Vol. 74 Issue 3, p423, 9 p.
- Publication Year :
- 1993
-
Abstract
- Clonal expansion of antagonized hematopoietic precursors results in severe promyelocytic leukemia. Retinoic acid-induced in vivo and in vitro blast maturations prevent this effect. Chromosome translocation with retinoic acid alpha-receptor gene (RAR-alpha) and PML gene-breakpoints accompanies this leukemia. Adoptive cell destruction lessens and retinoic acid sensitivity increases on PML-RAR-alpha protein expression in specific myeloid precursor cells.
- Subjects :
- Hematopoiesis -- Influence
Leukemia -- Causes of
Biological sciences
Subjects
Details
- ISSN :
- 00928674
- Volume :
- 74
- Issue :
- 3
- Database :
- Gale General OneFile
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.14522127