Advances in total synthesis of biologically important marine macrolides

Advances in the total synthesis of biologically important marine macrolides are described. Total synthesis of biologically important marine macrolides like spongistatin 1/altohyrtin, spongistatin 2/altohyrtin, dictyostatin, peloruside A, leucascandrolide A, callipeltoside A and ent-miyakolide are successfully achieved and these syntheses also served to confirm or establish the absolute stereo structures of the marine macrolides.