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The Drosophila anachronism locus: a glycoprotein secreted by glia inhibits neuroblast proliferation
- Source :
- Cell. July 16, 1993, Vol. 74 Issue 1, p15, 13 p.
- Publication Year :
- 1993
-
Abstract
- The product of Drosophila anachronism (ana) locus, a glycoprotein secreted by Gila cells, maintains the quiescent stage of postembryonic neuroblast growth. The ana locus regulates the proliferation of neuronal stem cells that generate the central nervous system. A unique secreted protein of 474 amino acids that is expressed in a subclass of nearby glial cell is encoded by ana. Ana regulates the timing of postembryonic neurogenesis by negatively controlling the proliferation of removal precursor cells.
- Subjects :
- Drosophila -- Analysis
Developmental neurology -- Research
Biological sciences
Subjects
Details
- ISSN :
- 00928674
- Volume :
- 74
- Issue :
- 1
- Database :
- Gale General OneFile
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.14419861