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Allosteric control of oligonucleotide hybridization by metal-induced cyclization

Authors :
Goritz, Mareike
Kramer, Roland
Source :
Journal of the American Chemical Society. Dec 28, 2005, Vol. 127 Issue 51, 18016-18017
Publication Year :
2005

Abstract

A stable, single-stranded DNA circle is smoothly formed from a linear precursor by metal Fe(sub 2+) assisted ring closure. With metal Zn(sub 2+), cyclization is reversible and a novel, complex type of allosteric regulation of hybridization is observed.

Details

Language :
English
ISSN :
00027863
Volume :
127
Issue :
51
Database :
Gale General OneFile
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
edsgcl.144073483