Synthesis of tertiary benzamides via Pd-catalyzed coupling of arylboronic esters and carbamoyl chlorides

Ortho-substituted arylboronic esters are efficiently coupled with carbamoyl chlorides under Pd-catalysis to give tertiary benzamides. A series of different carbamoyl chlorides are coupled with selected arylboronic esters to investigate the scope of the reaction with respect to the carbamoyl chlorides.