Stimulation of human thyroid growth via the inhibitory guanine nucleotide binding (G) protein Gi: constitutive expression of the G-protein alpha subunit Gi(alpha-1) in autonomous adenoma

Authors :: Selzer, Edgar
Wilfing, Astrid
Schiferer, Arno
Hermann, Michael
Grubeck-Loebenstein, Beatrix
Freissmuth, Michael
Source :: Proceedings of the National Academy of Sciences of the United States. Feb 15, 1993, Vol. 90 Issue 4, p1609, 5 p.
Publication Year :: 1993
Abstract: The G proteins controlling the adenylyl cyclase in thyroid autonomous adenoma were investigated. The results showed that stimulation of thyroid growth in autonomous adenoma involves alterations in the alpha-1 subunit of the inhibitory G protein Gi. The alterations in this subunit of Gi leads to unregulated expression of the alpha subunit, which may be associated with autonomous growth of thyroid adenomas.

Subjects :: G proteins -- Physiological aspects
Adenylate cyclase -- Physiological aspects
Adenomatous goiter -- Research
Science and technology

ISSN :: 00278424
Volume :: 90
Issue :: 4
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.14307404

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