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An elementary reaction step of the proton pump is revealed by mutation of tryptophan-164 to phenylalanine in cytochrome c oxidase from paracoccus denitrificans

Authors :
Ribacka, Camilla
Verkhovsky, Michael I.
Belevich, Ilya
Bloch, Dmitry A.
Puustinen, Anne
Wikstrom, Martem
Source :
Biochemistry. Dec 20, 2005, Vol. 44 Issue 50, p16502, 11 p.
Publication Year :
2005

Abstract

The redox-active centers of cytochrome c oxidase from P. denitrificans together with key amino acids, W164, E278, R473 and R474 are discussed. The DELTA-propionate of heme a(sub 3) is stabilized by hydrogen bonds from W164 and R473 and by charge interactions with R473 and R474.

Details

Language :
English
ISSN :
00062960
Volume :
44
Issue :
50
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.142995148