An efficient synthesis of the natural tetrahydrofuran pachastrissamine starting from D-ribo-phytosphingosine

Authors :: van den Berg, Richard J.B.H.N.
Boltje, Thomas J.
Verhagen, Carlo P.
Litjens, Remy E.J.N.
van der Marel, Gijsbert A.
Overkleeft, Herman S.
Source :: Journal of Organic Chemistry. Jan 20, 2006, Vol. 71 Issue 2, 836-839
Publication Year :: 2006
Abstract: A fast and efficient synthesis of the cytotoxic natural agent, pachstrissamine, and its unnatural 4-epi-congener, starting from phytosphingosine is described. The natural product pachastrissamine was synthesized in three steps and with 72% overall yield from D-ribo-phytosphingosine.

Subjects :: Tetrahydrofuran -- Structure
Tetrahydrofuran -- Properties
Nuclear magnetic resonance spectroscopy -- Analysis
Chromatography -- Analysis
Biological sciences
Chemistry

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