In the presence of dexamethasone, gamma interferon induces rat oligodendrocytes to express major histocompatibility complex class II molecules

Authors :: Bergsteinsdottir, K.
Brennan, A.
Jessen, K.R.
Mirsky, R.
Source :: Proceedings of the National Academy of Sciences of the United States. Oct 1, 1992, Vol. 89 Issue 19, p9054, 5 p.
Publication Year :: 1992
Abstract: An in vitro system capable of inducing oligodendrocytes to express class II major histocompatibility (MHC) mRNA and surface antigens was developed. MHC expression was achieved by treating the oligodendrocytes with interferon-gamma in a medium containing the synthetic glucocorticoid, dexamethasone. This class II MHC expression in oligodendrocytes may provide a mechanism of cell-type-specific killing by class II-restricted T cells in human demyelinating diseases.

Subjects :: Dexamethasone -- Usage
Interferon gamma -- Usage
Cell culture -- Methods
Oligodendroglia -- Research
Major histocompatibility complex -- Research
Demyelination -- Causes of
Science and technology

ISSN :: 00278424
Volume :: 89
Issue :: 19
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.14264584

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