Centromere DNA mutations induce a mitotic delay in Saccharomyces cerevisiae

Authors :: Spencer, Forrest
Hieter, Philip
Source :: Proceedings of the National Academy of Sciences of the United States. Oct 1, 1992, Vol. 89 Issue 19, p8908, 5 p.
Publication Year :: 1992
Abstract: A series of Saccharomyces cerevisiae mutant strains were generated by mutating centromere DNA (CEN) elements which did not markedly affect chromosome segregation. Characterization of these mutants showed that they could undergo DNA synthesis in similar rates as wild-type kinetics, but were delayed near the metaphase/anaphase transition. It is proposed that such a delay constitutes a mechanism to stabilize chromosomes with defective centromeres. This mechanism may be mediated by a surveillance system that monitors the completion of chromosomal attachment to the spindle fibers.

Subjects :: Saccharomyces -- Genetic aspects
Cell cycle -- Research
Cellular control mechanisms -- Identification and classification
Mitosis -- Research
Science and technology

ISSN :: 00278424
Volume :: 89
Issue :: 19
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.14264350

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