HTP-1 coordinates synaptonemal complex assembly with homolog alignment during meiosis in C. elegans

The mechanisms responsible for homolog alignment, synapsis and recombination are closely coordinated during meiosis in order to culminate in the formation of crossovers capable of directing accurate chromosome segregation. The study has identified that HTP-1 is a key regulator of synapsis that is required to prevent premature assembly of SC components relative to homolog alignment during meiosis and also HIM-3 family of proteins plays a key role in coordinating of early meiotic events.