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Stereocontrolled syntheses of Kainoid amino acids from 7-azabicyclo[2.2.] heptadienes using tandem radical addition-homoallylic radical rearrangement
- Source :
- Journal of Organic Chemistry. Oct 28, 2005, Vol. 70 Issue 22, p8866, 11 p.
- Publication Year :
- 2005
-
Abstract
- A full account of extension and adaptation of the methodology to the addition of carbon-based radicals to 7-azabicyclo[2.2.1]heptadienes is presented. Oxidative cleavage of the resulting 2-azabicyclo[2.2.1]hept-5-enes provide straightfoward access to polysubstituted pyrrolidines and in particular an efficient entry to the Kainoid amino acids.
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 70
- Issue :
- 22
- Database :
- Gale General OneFile
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.142559157