Volatile anesthetics compete for common binding sites on bovine serum albumin: a 19F-NMR study

Authors :: Dubois, Brian W.
Cherian, Sebastian F.
Evers, Alex S.
Source :: Proceedings of the National Academy of Sciences of the United States. July 15, 1993, Vol. 90 Issue 14, p6478, 5 p.
Publication Year :: 1993
Abstract: 19F-NMR T2 relaxation was employed to study whether other volatile anesthetics besides isoflurane bind to the same fatty acid-displaceable regions on serum albumin, and whether they differ in their attraction to these regions. Three other flurinated volatile anesthetics, halothane, methoxyflurane and sevoflurane, bind with differing attraction to fatty-acid displaceable regions on serum albumin, and impair isoflurane binding competitively. Several different volatile anesthetics can compete for binding to particular regions on a rotein.

Subjects :: Serum albumin -- Analysis
Nuclear magnetic resonance spectroscopy -- Usage
Science and technology

ISSN :: 00278424
Volume :: 90
Issue :: 14
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.14240370

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